Study of Presenilins as a possible Prophylactic Drug Target for the Treatment of Alzheimer’s Disease.
Project Aim(s): To utilise brain organoids to investigate the aetiology of Alzheimer's disease.
Does Bexarotene reverse Calcium Dysregulation in a Murine Model of Alzheimer’s Disease?
Project Aim(s): To determine if the ApoE stimulator, bexarotene, can restore dysregulated calcium homeostasis in hippocampal neurons from transgenic AD mice.
Applied Research Projects in Dementia: Towards Resilience in Family Caregiving for People with Dementia.
Project Aim(s): To develop and promote resilience in family carers of people with dementia.
BIOMARKAPD (Biomarker Optimisation in AD & PD).
Alzheimer’s and Parkinson’s diseases (AD and PD) are the two most common neurodegenerative conditions. They cause major costs for society and suffering and death for millions of patients around the globe. In Europe, more than 8 million individuals have AD or PD. Current treatments are symptomatic but do not stop the underlying disease process. Using biomarkers, we can detect biochemical changes that show when neurons start to die. There are also biochemical tests for brain changes that are specific to AD and PD.
Targeting Glial Plasticity to Alleviate Age-related Loss of Neuronal Function in AD.
Project Aim(s): To determine the role of neuroinflammation in driving neurodegeneration.
NeuroSKILL - Neuroimaging Skills in Dementia.
Project Aim(s):
The project has various complementary aims: (a) research on normal ageing and Alzheimer's disease using MRI-based methods, (b) develop training programmes in neuroimaging in dementia, (c) develop greater understanding of the use of neuroimaging by clinicians for diagnosis of Alzheimer's disease, (d) technology transfer between centres.
Investigating Ageing-related Deficits in Cognition: A Combined Multimodal fMRI-DTI.
Project Aim(s): The objective is the assessment of the impact of alterations of white matter tract integrity on effective connectivity in the neural network underpinning working memory. Using brain imaging data it will examine the associations between brain structure and function in young and older healthy participants and how normal ageing alters the relationship between structure and function.
Health Professional Fellowship: Environmental and Genetic Epidemiology of Amyotrophic Lateral Sclerosis.
Amyotrophic Lateral Sclerosis (ALS) is a terminal neuro-degenerative disorder of adults, typically having rapid progression and involving both motor and cognitive function. ALS exhibits considerable heterogeneity of both symptom profile and progression. Nevertheless, median survival is typically under three years from disease onset. ALS is the most common motor neurone disease in adults, with an incidence of 2 to 3 per 100,000 in Europe.
Diet Modification to prevent Aspiration in People with Dementia and Dysphagia.
To determine the evidence for diet modification - Specifically, thickening fluids to prevent aspiration in people with dementia and swallowing difficulties.