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Research

DRNI Members Research is a list of ongoing and completed research carried out by DRNI members.
You can search via project type, disease, or Principal Investigator/Researcher name.

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Research type

  • Research project (88)
  • Research initiative (30)

Disease area

  • Dementia (including Alzheimer's Disease and other dementias) (49)
  • Motor Neurone Disease (14)
  • Parkinson's Disease and related disorders (13)
  • Neurodegenerative Disease (11)
  • Not specified (1)

Field of research

  • Basic/Discovery Research (37)
  • Clinical Research (26)
  • Social Research (8)
  • Public Health (6)
  • Connected Health (5)
  • Economic Research (4)
  • Brain Health (2)

Deciphering ALS Heterogeneity: A Precision Medicine Approach to Network-based Biomarker Development.

Project Aim(s):

(i) To continue to characterise the clinical subphenotypes of ALS and to further elucidate the observed clinical and genetic overlap between ALS and neuropsychiatric disorders by detailed study of endophenotypes in first and second degree relatives.

(ii) To identify heterogeneous disease subcohorts based on genomic signatures, including those that overlap between ALS and neuropsychiatric illness.

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Defining and Addressing the Complex Needs of ALS Caregivers (ALSA-Cog).

Project Aim(s):

(i) Using existing data, to characterize the impact of ALS stage, cognitive and behavioural effects in ALS on caregiver burden, and to ascertain the unmet psychological and psychosocial needs of caregivers.

(ii) To provide new data focussing on subjective and objective aspects of caregiver burden that can inform psychologically tailored interventions that enable self-management of carer burden.

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Dementia Elevator

Dementia Elevator is an education and empowerment programme developed by DCU and the HSE (with the support of Atlantic Philanthropies) to help individuals, communities and health professionals to engage appropriately with people with dementia. Among its objectives are dementia awareness training and the delivery of training/information programmes to the general public, health professionals, individuals and family caregivers.

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Developing a National Dementia Strategy for Ireland.

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Developing Objective Biomarkers of Cognitive Ageing and Cognitive Reserve.

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Diagnosis and Disclosure of Dementia – A Comparative Qualitative Study of Irish and Swedish General Practitioners.

Project Aim(s): To explore the attitudes of Irish and Swedish General Practitioners (GPs) to the diagnosis and disclosure of dementia to patients; to investigate GP under-graduate/post-graduate training in dementia; to examine the post-diagnostic support services available to GPs in both countries and to investigate the extent to which dementia is perceived as stigmatising.

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Diet Modification to prevent Aspiration in People with Dementia and Dysphagia.

To determine the evidence for diet modification - Specifically, thickening fluids to prevent aspiration in people with dementia and swallowing difficulties.

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DNA Triplet Expansions and Neurological Disease.

Project Aim(s):To decipher the causal link between histone deacetylases and triplet repeat expansions.

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Does Bexarotene reverse Calcium Dysregulation in a Murine Model of Alzheimer’s Disease?

Project Aim(s): To determine if the ApoE stimulator, bexarotene, can restore dysregulated calcium homeostasis in hippocampal neurons from transgenic AD mice.

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Dublin Brain Bank

The Dublin Brain Bank is a collaboration between the Neuropathology Department of Beaumont Hospital and the Royal College of Surgeons in Ireland. It aims to facilitate an archive of brain tissue, which will help clinical and neuroscience researchers uncover potential cures for neurological diseases.

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  • Trinity College Dublin
  • University College Dublin
  • University College Cork
  • Dublin City University
  • National University of Ireland, Galway
  • The Alzheimer Society of Ireland
  • Health Research Board
  • Royal College of Surgeons in Ireland
  • University of Ulster
  • Queen's University Belfast
  • SPHeRE
  • Dementia - Understand Together
  • Trinity College Institute of Neuroscience
  • Engaging Dementia logo
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