Project Aim(s):To decipher the causal link between histone deacetylases and triplet repeat expansions.
Research
DRNI Members Research is a list of ongoing and completed research carried out by DRNI members.
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Project Aim(s): To determine if the ApoE stimulator, bexarotene, can restore dysregulated calcium homeostasis in hippocampal neurons from transgenic AD mice.
The Dublin Brain Bank is a collaboration between the Neuropathology Department of Beaumont Hospital and the Royal College of Surgeons in Ireland. It aims to facilitate an archive of brain tissue, which will help clinical and neuroscience researchers uncover potential cures for neurological diseases.
The Dublin Brain Bank is a collaboration between the Neuropathology Department of Beaumont Hospital and the Royal College of Surgeons in Ireland. It aims to facilitate an archive of brain tissue, which will help clinical and neuroscience researchers uncover potential cures for neurological diseases.
This research programme focuses on the economic, social, health and emotional costs of caring for people with dementia. The research will provide longitudinal estimates of the relationships between informal care costs and cognitive function, comorbidities and behavioural changes in people with dementia, including an exploration of the potential of psychosocial interventions and technology-based interventions for care-givers to ameliorate the potential burden of care.
To develop a self-report questionnaire that measures the fears and coping strategies that develop in response to memory loss
Dementia is a costly condition and one that differs from other conditions in the significant cost burden placed on informal caregivers. The aim of this analysis was to estimate the economic and social costs of dementia in Ireland in 2010. With an estimate of 41,470 people with dementia, the total baseline annual cost was found to be over €1.69 billion, 48% of which was attributable to the opportunity cost of informal care provided by family and friends and 43% to residential care.
Project Aim(s): To discover new causative and disease-modifying pathways to pave the way for novel therapies.
Cognitive stimulation therapy (CST) is the only evidence-based intervention that improves cognition and quality of life for people with mild-moderate dementia. CST offers an ideal solution to the demand for early interventions for those with dementia in Ireland.