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Research

DRNI Members Research is a list of ongoing and completed research carried out by DRNI members.
You can search via project type, disease, or Principal Investigator/Researcher name.

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Research type

  • Research project (88)
  • Research initiative (30)

Disease area

  • Dementia (including Alzheimer's Disease and other dementias) (49)
  • Motor Neurone Disease (14)
  • Parkinson's Disease and related disorders (13)
  • Neurodegenerative Disease (11)
  • Not specified (1)

Field of research

  • Basic/Discovery Research (37)
  • Clinical Research (26)
  • Social Research (8)
  • Public Health (6)
  • Connected Health (5)
  • Economic Research (4)
  • Brain Health (2)

Intellectual Disability Supplement to TILDA (IDS-TILDA)

IDS-TILDA is a longitudinal study researching ageing in Ireland among people with an intellectual disability aged 40 and over (n=approximately 750 people). Individuals with an intellectual disability, particularly those with Down Syndrome are at an increased risk of developing an Alzheimer’s related dementia. The IDS-TILDA collects information on Intellectual Disability and Dementia.

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Inter-Regional Synaptic Integration of Sensorimotor Signals within Episodic Memory Networks.

The successful treatment of memory impairments and neurodegenerative disorders critically depends on our understanding of the storage and recollection of memory episodes. Specifically, an understanding of the interaction between amnesic and neurodegenerative syndromes would aid the development of effective treatments. One of the key questions in neuroscience is: how do brain networks encode experience-dependent memory? Answering this question will give us a universal tool to treat multiple brain disorders.

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Investigating Ageing-related Deficits in Cognition: A Combined Multimodal fMRI-DTI.

Project Aim(s): The objective is the assessment of the impact of alterations of white matter tract integrity on effective connectivity in the neural network underpinning working memory.  Using brain imaging data it will examine the associations between brain structure and function in young and older healthy participants and how normal ageing alters the relationship between structure and function.

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Investigation of Early Stage Changes in Memory Brain Networks in Preclinical Alzheimer's Disease.

Increased knowledge about the pre-clinical and early clinical stages of Alzheimer's disease (AD) will be key in developing preventative strategies for the disease as well as development of therapeutic treatment strategies. In addition, this approach will contribute to the development of biomarkers for the early diagnosis of AD.

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Irish National Audit of Demetia Care in Acute Hospitals (INAD)

In 2013, the Irish National Audit of Dementia audited 35 acute hospitals in the Republic of Ireland, interviewing the senior hospital managers and geriatricians; directly observing the environment/ interviewing the clinical nurse manager of 77 wards, and reviewing 660 healthcare records of people with dementia who had been admitted to the hospitals.

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Irish Network for Biomarkers in Neurodegeneration (IN-BIND)

As part of the BIOMARKPD initiative the Irish Network for Biomarkers in Neurodegeneration (IN-BIND) was established. It is a research infrastructure aimed at creating a functional network for clinical and laboratory based scientists working in this area. Similar to BIOMARKPD, the aims of IN-BIND are the standardisation of biomarker measurement across Ireland and Europe to include i) sample collection, ii) measurement, iii) and interpretation.

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Irish Network for Biomarkers in Neurodegeneration (IN-BIND)

As part of the BIOMARKPD initiative the Irish Network for Biomarkers in Neurodegeneration (IN-BIND) was established. It is a research infrastructure aimed at creating a functional network for clinical and laboratory based scientists working in this area. Similar to BIOMARKPD, the aims of IN-BIND are the standardisation of biomarker measurement across Ireland and Europe to include i) sample collection, ii) measurement, iii) and interpretation.

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Living and Dying with Amyotrophic Lateral Sclerosis: A Population based Analysis of Palliative Needs, Services and Outcomes in Non-malignant Terminal Illness

Adopting a three pronged multidisciplinary research approach the programme is organised in three specific and interlinked work packages relating to Amyotrophic Lateral Scerosis, spanning clinical, epidemiological and health services research including health economics. The research aims to generate a framework for optimal management of ALS and explore its relevance for other neurological conditions.

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Living and dying with Amyotrophic Lateral Sclerosis: A Population based Analysis of Palliative Needs, Services and Outcomes in non-malignant terminal illness.

Project Aim(s): This project aimed to utilize data from the Irish Register and the national ALS service to generate a framework for care for Irish ALS patients based on their clinical phenotype,  rate of progression and long term prognosis.  The objective was to design, estimate the costs, and measure the benefits of a multifaceted care programme that incorporates the key clinical and prognostic elements of ALS.  

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Living and Dying with Amyotrophic Lateral Sclerosis: A Population based Analysis of Palliative Needs, Services and Outcomes in Non-malignant Terminal Illness

Adopting a three pronged multidisciplinary research approach the programme is organised in three specific and interlinked work packages relating to Amyotrophic Lateral Scerosis, spanning clinical, epidemiological and health services research including health economics. The research aims to generate a framework for optimal management of ALS and explore its relevance for other neurological conditions.

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  • Trinity College Dublin
  • University College Dublin
  • University College Cork
  • Dublin City University
  • National University of Ireland, Galway
  • The Alzheimer Society of Ireland
  • Health Research Board
  • Royal College of Surgeons in Ireland
  • University of Ulster
  • Queen's University Belfast
  • SPHeRE
  • Dementia - Understand Together
  • Trinity College Institute of Neuroscience
  • Engaging Dementia
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