Darragh O’Brien is a Group Leader in Translational Proteomics and Neurodegenerative Disease at the Nuffield Department of Medicine, University of Oxford, where he utilises biological mass spectrometry to decipher mechanisms of human disease. His research interests lie in how protein intrinsic disorder and post-translational modifications such as phosphorylation and ubiquitination contribute to protein function and disease, with a focus on the tauopathies Alzheimer's Disease and Progressive Supranuclear Palsy.