Therapeutic Benefits of Isotype Selective HDAC Inhibition in HD.
Project Aim(s): To execute preclinical testing of an HDAC3-specific inhibitor for disease prevention in Huntington's disease (HD).
DNA Triplet Expansions and Neurological Disease.
Project Aim(s):To decipher the causal link between histone deacetylases and triplet repeat expansions.
Marie Skłodowska-Curie Actions.
Project Aim(s): To investigate bone morphogenetic protein 2 as a therapeutic for Parkinson's disease (PD).
SFI CDA: Development of GDF-5 Neurotrophic Therapy for Parkinson’s Disease.
Project Aim(s): The development of neurotrophic factor therapy for Parkinson's disease (PD).
The Impact of Neuroinflammatory Changes in Deteriorating Cognitive Function in Age and a Model of Alzheimer’s Disease.
To assess whether targeting microglia, and consequently neuroinflammation, can restore impaired cognitive function in age and a model of Alzheimer’s disease.
HeLoCog: Age-related Hearing Loss, Cognitive Function, and the Moderating Roles of Social Isolation and Loneliness.
Aim(s):
(i) To characterise patterns of hearing problems and of hearing aid use in NICOLA and to compare these patterns in a qualitative fashion with those found in TILDA.
(ii) To evaluate the cross-sectional relationship between hearing problems and cognitive functioning, using regression modelling.
(iii) To evaluate loneliness, social isolation, and social engagement as moderators of the putative relationship between hearing problems and cognitive functioning, using a structural equation modelling approach.
Alcohol Consumption & Brain Health in Older Adults Across the Island of Ireland.
Aims are to:
1. Characterise and compare alcohol consumption patterns in older adults in Ireland
2. Determine associations between alcohol patterns and cognitive function
Social Determinants of Cognitive Decline among Older Irish Adults: Direct and Indirect Pathways.
Aim: to elucidate the direct and indirect pathways between social determinants and cognitive decline among older Irish adults, to further understand and identify potential points of intervention in the progression of cognitive decline.
Primary objectives:
An Examination of Virtual Reality Technology in the Training of Health Professionals and Carers.
Aim(s): To examine the impact of VR on the understanding of emotions, cognitions and behaviours for people living with dementia among health professionals and carers.
Health and Loneliness in Older Adults.
The proposed research aims to create empirical evidence regarding the impact of befriending services on health and loneliness, assisting ALONE in developing and refining their mission statement. The research question is: “Do befriending services improve health (measured as health-related quality of life and cognitive function), and do they mitigate the impact of loneliness on health?” A secondary aim is to identify, using exploratory methods, potential mechanisms through which befriending impacts health.