Putting the Brakes on Alzheimer's Disease: Exercise and its Effects on Cognitive Decline, Neurogenesis and Inflammation in the APP/PS-1 Mouse.
The overall aim of this research is to examine the effect of regular exercise on:
1) Adult hippocampal neurogenesis
2) Cognitive performance in hippocampus-dependent memory tasks
3) Microglial activation and neuroinflammatory profile using the transgenic mouse model of Alzheimer’s Disease [amyloid precursor protein (APP)SWE/presenilin-1 (PS-1)].