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Investigating sex-specific influences of gut microbiome on Alzheimer’s disease (SIGMA)

Women are twice as likely as men to develop Alzheimer’s disease, particularly in later life. While hormonal differences between biological sexes have been suggested as a potential explanation for this disparity, the exact reasons remain unclear. Recently, the gut microbiome has emerged as a key area of interest in Alzheimer’s research due to its role in disease progression and observed differences between males and females.

LINGO1 a novel regulatory subunit of BK channels implicated in tremor

Parkinson’s disease is a debilitating disorder characterized by uncontrolled limb shaking (tremor), slow movement, dementia and depression. It is the second most common age-related neurodegenerative disease affecting ~10 million worldwide, yet the causes of tremor are poorly understood and treatment is wholly inadequate. Tremor is linked to proteins called ion channels. These tiny molecular pores are studded into the cell membrane, permit the flow of ions through it and help to control nerves.

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