Neurodegenerative Disease

Investigating COVID-19-related loneliness and social isolation in carers of people with brain health challenges in Ireland

SFI Centre for Research Training in Genomic Data Science.

We are a PhD training programme, linking together approximately 90 genomics data science group leaders based at five Irish institutions. Expertise within the group spans from statistical modeling and machine learning to the full range of application of genomics. Over the coming four years our research teams will be joined by 100 fully funded PhD students, recruited through this Centre.

Control of Neuronal Proteostasis by Stress-induced Transfer RNA Fragments (‘tiRNA’) as a common Stress Pathway across Neurodegenerative Disorders.

Project Aim(s):

(i) To Identify tiRNA/sncRNA fingerprints in AD, ALS, FTD and PD human disease i-neurons.

(ii) To determine if tiRNAs affect the survival of i-neurons from controls and ALS, PD and FTD models.

The Frail Brain and the Frail Body: Impact of Frailty and Cognitive Impairment on Trajectories, Patterns and Costs in Care in Old Age.

SFI Investigator Programme: Conformational Triggers, Mechanisms and Pathways for Neurodegenerative Disease.

Project Aim(s): To examine how Ataxin-2 and Stress_Granule Modulatory Proteins function in ALS/FTD.

Translational Control of Neuronal MRNAs: Roles in Membranes and ND.

Biological Resource Analysis to Identify New Mechanisms and Phenotypes in Neurodegenerative Diseases (BRAIN-MEND).

Project Aim(s): Our overall aim is to revise existing phenotypic classifications using pathways and network analyses to generate newer more biologically classifications based on causative mechanisms, potential new therapeutic drug targets and indications, treatment response profiles and clinical sub-phenotypes.