SFI Centre for Research Training in Genomic Data Science.
We are a PhD training programme, linking together approximately 90 genomics data science group leaders based at five Irish institutions. Expertise within the group spans from statistical modeling and machine learning to the full range of application of genomics. Over the coming four years our research teams will be joined by 100 fully funded PhD students, recruited through this Centre.
Control of Neuronal Proteostasis by Stress-induced Transfer RNA Fragments (‘tiRNA’) as a common Stress Pathway across Neurodegenerative Disorders.
Project Aim(s):
(i) To Identify tiRNA/sncRNA fingerprints in AD, ALS, FTD and PD human disease i-neurons.
(ii) To determine if tiRNAs affect the survival of i-neurons from controls and ALS, PD and FTD models.
SFI Investigator Programme: Conformational Triggers, Mechanisms and Pathways for Neurodegenerative Disease.
Project Aim(s): To examine how Ataxin-2 and Stress_Granule Modulatory Proteins function in ALS/FTD.
Biological Resource Analysis to Identify New Mechanisms and Phenotypes in Neurodegenerative Diseases (BRAIN-MEND).
Project Aim(s): Our overall aim is to revise existing phenotypic classifications using pathways and network analyses to generate newer more biologically classifications based on causative mechanisms, potential new therapeutic drug targets and indications, treatment response profiles and clinical sub-phenotypes.
Understanding Mechanisms of HDAC3 and 5 HDAC5 in Controlling MutSbeta in Trinuceotide Repeat Expansions Approved.
Project Aim(s): To understand how triplet repeat expansions are controlled in cells and how this information might be useful clinically.
Therapeutic Benefits of Isotype Selective HDAC Inhibition in HD.
Project Aim(s): To execute preclinical testing of an HDAC3-specific inhibitor for disease prevention in Huntington's disease (HD).
DNA Triplet Expansions and Neurological Disease.
Project Aim(s):To decipher the causal link between histone deacetylases and triplet repeat expansions.
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