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Is Ireland prepared for the new disease-modifying therapies (DMT) for Alzheimer’s? Scoping perspectives and attitudes of lay stakeholders

No new Alzheimer's drug treatment had be licensed for 20 years until 2021, when the first Alzheimer's disease-modifying therapy (DMT) was licensed in the USA, giving hope of slowing/reversing the disease. Several new DMTs are expected. Unfortunately, offering DMTs in Ireland requires significant changes in Memory Clinic set-up, due to high drug costs and need for careful monitoring. Moreover, DMTs only work in people in early Alzheimer's, which is often unrecognized in Ireland.

PROMED-EX Randomised Controlled Trial: Effects of PROtein enriched MEDiterranean Diet and EXercise on nutritional status and cognition in adults at risk of undernutrition and cognitive decline.

The PROtein enriched MEDiterranean Diet and EXercise (PROMED-EX) randomised controlled trial (RCT) aims to determine the efficacy of a protein-enriched Mediterranean diet, with and without exercise, in comparison with standard care, on nutritional status and cognition in adults at risk of undernutrition with subjective cognitive decline. The project will explore the mechanistic pathways in diet-exercise induced change in nutritional status and cognition.

What helps the carers? A qualitative study of the media supports used by Irish families who care for a loved one with dementia

Our research aims to explore media supports used by Irish families who care for or have recently cared for a loved one with dementia. Media supports may include podcasts, radio shows, television programmes or adverts, websites, apps, physical information sheets, and other forms of information provision. We want to find out if Irish families caring for a loved one with dementia use resources of this type, if they are suitable, and how they are used in dementia care.

Caffeine as a therapeutic option for Alzheimer's disease

Mounting evidence suggests that dietary caffeine intake may exert some beneficial effects in reducing dementia risk and possibly Alzheimer’s disease, and may be a viable therapeutic approach. Clinical studies also suggest that caffeine is a cognitive normalizer and not a cognitive enhancer. Moreover, some clinical studies suggest the neuroprotective effect of caffeine might be confounded by gender.

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