Mechanisms underlying the role of gut-microbiota in exercise-induced changes in cognitive function in middle-age
Middle age is a critical time for cognitive changes that may precede dementia onset. Interestingly, studies have shown that lifestyle factors such as exercise can reverse age-related cognitive decline and improve memory function. However, the underlying mechanisms that underpin these effects are unknown. Besides a decline in physical fitness, middle age is characterized by extensive change in gastrointestinal function, gut microbiota composition, and related metabolites.