POWER will identify the immune-metabolic and nutritional signatures associated with cognitive impairment in ageing and depression. A clinical trial investigating effects of diet, physical activity, and brain training on cognition and depressive symptoms will be conducted. The role of gut microbiota in mediating the beneficial effects of these interventions on cognitive outcomes, depressive symptoms, hippocampal neurogenesis and inflammation will then be conducted in an animal model.
Disease area
Depression; cognitive decline
Field of research
Neurodegeneration
Principal Investigator/ Researcher Names
Professor Yvonne M. Nolan
Professor Olivia O’Leary
Institution
University College Cork (UCC)
Funding body
Health Research Board under the umbrella of the Partnership Fostering a European Research Area for Health (ERA4Health).
Start date
Project completed
No
Are you looking to Recruit Research Participants?
No