Project Aim(s): This study aims to contribute to improving quality of life for people with end stage dementia living in residential care settings by investigating the experiences of elderly spouses whose relatives died with end-stage dementia in nursing homes in both Northern Ireland (NI) and the Republic of Ireland (RoI). A second aim is to develop guidelines for nursing home staff for the delivery of quality care in residents with end stage dementia in residential institutions.
Research
DRNI Members Research is a list of ongoing and completed research carried out by DRNI members.
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Amyotrophic Lateral Sclerosis (ALS) is a terminal neuro-degenerative disorder of adults, typically having rapid progression and involving both motor and cognitive function. ALS exhibits considerable heterogeneity of both symptom profile and progression. Nevertheless, median survival is typically under three years from disease onset. ALS is the most common motor neurone disease in adults, with an incidence of 2 to 3 per 100,000 in Europe.
To develop accessible best practice guidelines for post-diagnostic dementia supports for people with an intellectual disability in Ireland. The project aims to:
(1) examine the current landscape of post-diagnostic care at a national level;
(2) consider barriers to access;
(3) incorporate existing best practices; and
(4) give due consideration of the experiences and recommendations of people with an intellectual disability living with dementia and of their families/carers.
Increased knowledge about the pre-clinical and early clinical stages of Alzheimer's disease (AD) will be key in developing preventative strategies for the disease as well as development of therapeutic treatment strategies. In addition, this approach will contribute to the development of biomarkers for the early diagnosis of AD.
Project Aim(s): This project aimed to utilize data from the Irish Register and the national ALS service to generate a framework for care for Irish ALS patients based on their clinical phenotype, rate of progression and long term prognosis. The objective was to design, estimate the costs, and measure the benefits of a multifaceted care programme that incorporates the key clinical and prognostic elements of ALS.
Project Aim(s):
The project has various complementary aims: (a) research on normal ageing and Alzheimer's disease using MRI-based methods, (b) develop training programmes in neuroimaging in dementia, (c) develop greater understanding of the use of neuroimaging by clinicians for diagnosis of Alzheimer's disease, (d) technology transfer between centres.
Project Aim(s): To test a software engine designed to optimize medication in multimorbid older patients aimed at preventing unplanned hospitral readmissions.
Project Aim(s): To develop and assess the feasibility of a theoretically-informed, evidence-based and sustainable intervention to rationalise antipsychotic prescribing in nursing home residents with dementia.
Project Aim(s): TUDCA-ALS will focus on amyotrophic lateral sclerosis (ALS) a rare neurodegenerative disorder. TUDCA-ALS is based on the results of a successful proof-of-concept trial and has the ambition to develop a novel therapy in patients with ALS, based on administration of tauroursodeoxycholic acid (TUDCA) in addition to riluzole. TUDCA-ALS aims to perform a state-of-art randomized control trial on safety and efficacy of TUDCA in patients with sporadic ALS, without cognitive involvement and to exploit the project results into a novel therapeutic treatment for ALS.
Project Aim(s): To test a software engine for the prevention of adverse drug reactions in multimorbid older patients hospitalized with acute illness.