Control of Neuronal Proteostasis by Stress-induced Transfer RNA Fragments (‘tiRNA’) as a common Stress Pathway across Neurodegenerative Disorders. Project Aim(s): (i) To Identify tiRNA/sncRNA fingerprints in AD, ALS, FTD and PD human disease i-neurons. (ii) To determine if tiRNAs affect the survival of i-neurons from controls and ALS, PD and FTD models. Continue reading