A Multidisciplinary Study on Cognition in Multiple Sclerosis; An Exploratory Proof of Concept Study using Novel Technology and a nested Longitudinal Study on the Impact of Cladribine Tablets on Cognitive and Behavioural Function in MS.

Project Aim(s): This proposal aims to combine our novel EEG based technology with detailed neuropsychological assessment to provide a quantitative measure of cognitive change in MS that could be used in a clinical trial setting.  The study will also  provide an opportunity to assess for the first time the impact of Cladribine on cognitive performance using conventional screening tools, detailed neuropsychological batteries, and experimental neurophysiology based paradigms that could be harnessed for future nested case control studies.

Principal Investigator/ Researcher Names

Prof. Orla Hardiman

Disease Area

Motor Neurone Disease

Field of Research

Clinical Research


Trinity College Dublin

Funding body

(i) Merck Serono Limited - €190,000

(ii) FutureNeuro SFI Research Centre - €190,000

Grant Awarded (€)


Start date

September 2019

End/expected end date

January 2023

Date of Expected Results/Outcomes

March 2023

Project Completed


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Research participants information


(i) Multiple sclerosis patients attending clinics in Beaumont or St. Vincent’s Hospitals.

(ii) Control participants, i.e. participants matched for age and sex without multiple sclerosis.