Assessing Cognitive Communication Skills in Dementia: A Scoping Review.
Project Aim(s): To review published cognitive–communication assessments to determine what psychometrically sound assessments exist that are applicable to all people with dementia.
How does Cerebrospinal Fluid from Alzheimer’s Disease Patients affect Human Cortical Forebrain Cerebroid Form and Function?
Project Aim(s): To determine the effect(s) of CSF from Alzheimer's disease (AD) patients on cerebroids cultured healthy human iPSCs and to identify the mediator(s) of AD-CSF-mediated pathology.
Study of Presenilins as a possible Prophylactic Drug Target for the Treatment of Alzheimer’s Disease.
Project Aim(s): To utilise brain organoids to investigate the aetiology of Alzheimer's disease.
Does Bexarotene reverse Calcium Dysregulation in a Murine Model of Alzheimer’s Disease?
Project Aim(s): To determine if the ApoE stimulator, bexarotene, can restore dysregulated calcium homeostasis in hippocampal neurons from transgenic AD mice.
Applied Research Projects in Dementia: Towards Resilience in Family Caregiving for People with Dementia.
Project Aim(s): To develop and promote resilience in family carers of people with dementia.
BIOMARKAPD (Biomarker Optimisation in AD & PD).
Alzheimer’s and Parkinson’s diseases (AD and PD) are the two most common neurodegenerative conditions. They cause major costs for society and suffering and death for millions of patients around the globe. In Europe, more than 8 million individuals have AD or PD. Current treatments are symptomatic but do not stop the underlying disease process. Using biomarkers, we can detect biochemical changes that show when neurons start to die. There are also biochemical tests for brain changes that are specific to AD and PD.