Project Aim(s): To discover new causative and disease-modifying pathways to pave the way for novel therapies.
Basic/Discovery Research
Project Aim(s): To understand the genetic basis of ALS and to ultimately find a cure for this devastating, fatal neuromuscular disease, Project MinE aims to analyse the DNA of at least 15,000 ALS patients and 7,500 control subjects. The resulting 22,500 DNA profiles will be compared.
Project Aim(s): To understand how triplet repeat expansions are controlled in cells and how this information might be useful clinically.
Project Aim(s):To decipher the causal link between histone deacetylases and triplet repeat expansions.
Project Aim(s): To investigate bone morphogenetic protein 2 as a therapeutic for Parkinson's disease (PD).
Project Aim(s): The development of neurotrophic factor therapy for Parkinson's disease (PD).
One promising approach for the treatment of PD is cellular brain repair whereby the cells that have died in the condition are replaced by transplantation of healthy cells into the brain. However, this approach has faced several limitations including poor survival of the transplanted cells in the PD brain. To address this limitation, we have recently shown that biomaterials - that is, materials that have been specifically engineered to interact with living systems for therapeutic purposes – have the potential to dramatically improve cellular brain repair for PD.
PMSMatTrain focuses on gaining a comprehensive understanding of the progressive phase of multiple sclerosis (PMS) from basics to translation, fully supported by eight beneficiaries (six research institutions and two SMEs).
The successful treatment of memory impairments and neurodegenerative disorders critically depends on our understanding of the storage and recollection of memory episodes. Specifically, an understanding of the interaction between amnesic and neurodegenerative syndromes would aid the development of effective treatments. One of the key questions in neuroscience is: how do brain networks encode experience-dependent memory? Answering this question will give us a universal tool to treat multiple brain disorders.
1. Overview of Research Plans.
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