Project Aim(s): TUDCA-ALS will focus on amyotrophic lateral sclerosis (ALS) a rare neurodegenerative disorder. TUDCA-ALS is based on the results of a successful proof-of-concept trial and has the ambition to develop a novel therapy in patients with ALS, based on administration of tauroursodeoxycholic acid (TUDCA) in addition to riluzole. TUDCA-ALS aims to perform a state-of-art randomized control trial on safety and efficacy of TUDCA in patients with sporadic ALS, without cognitive involvement and to exploit the project results into a novel therapeutic treatment for ALS.
Research
DRNI Members Research is a list of ongoing and completed research carried out by DRNI members.
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Project Aim(s): Development of optimally informative biomarkers for ALS, and establishment of stakeholder agreement regarding their use. This will be achieved by defining, validating and harmonizing optimal methodologies that can be reliably implemented within a pan-European framework program.
Project Aim(s): To test a software engine for the prevention of adverse drug reactions in multimorbid older patients hospitalized with acute illness.
Project Aim(s): The development of neurotrophic factor therapy for Parkinson's disease (PD).
We are a PhD training programme, linking together approximately 90 genomics data science group leaders based at five Irish institutions. Expertise within the group spans from statistical modeling and machine learning to the full range of application of genomics. Over the coming four years our research teams will be joined by 100 fully funded PhD students, recruited through this Centre.
Project Aim(s): To examine how Ataxin-2 and Stress_Granule Modulatory Proteins function in ALS/FTD.
Aim: to elucidate the direct and indirect pathways between social determinants and cognitive decline among older Irish adults, to further understand and identify potential points of intervention in the progression of cognitive decline.
Primary objectives:
To investigate the psychosocial effects of the introduction of an adaptive Irish Céilí dance group activity with people living with dementia and their carers.
Project Aim(s): To utilise brain organoids to investigate the aetiology of Alzheimer's disease.