Biological Resource Analysis to Identify New Mechanisms and Phenotypes in Neurodegenerative Diseases (BRAIN-MEND).
Project Aim(s): Our overall aim is to revise existing phenotypic classifications using pathways and network analyses to generate newer more biologically classifications based on causative mechanisms, potential new therapeutic drug targets and indications, treatment response profiles and clinical sub-phenotypes.
Therapeutic Benefits of Isotype Selective HDAC Inhibition in HD.
Project Aim(s): To execute preclinical testing of an HDAC3-specific inhibitor for disease prevention in Huntington's disease (HD).