Applied Research Projects in Dementia: Validation of the Profile for Communication Abilities in Dementia (P-CAD).
Project Aim(s): To validate a cognitive communication assessment for people with dementia.
Inter-Regional Synaptic Integration of Sensorimotor Signals within Episodic Memory Networks.
The successful treatment of memory impairments and neurodegenerative disorders critically depends on our understanding of the storage and recollection of memory episodes. Specifically, an understanding of the interaction between amnesic and neurodegenerative syndromes would aid the development of effective treatments. One of the key questions in neuroscience is: how do brain networks encode experience-dependent memory? Answering this question will give us a universal tool to treat multiple brain disorders.
Putting the Brakes on Alzheimer's Disease: Exercise and its Effects on Cognitive Decline, Neurogenesis and Inflammation in the APP/PS-1 Mouse.
The overall aim of this research is to examine the effect of regular exercise on:
1) Adult hippocampal neurogenesis
2) Cognitive performance in hippocampus-dependent memory tasks
3) Microglial activation and neuroinflammatory profile using the transgenic mouse model of Alzheimer’s Disease [amyloid precursor protein (APP)SWE/presenilin-1 (PS-1)].