A Multidisciplinary Study on Cognition in Multiple Sclerosis; An Exploratory Proof of Concept Study using Novel Technology and a nested Longitudinal Study on the Impact of Cladribine Tablets on Cognitive and Behavioural Function in MS.

Project Aim(s): This proposal aims to combine our novel EEG based technology with detailed neuropsychological assessment to provide a quantitative measure of cognitive change in MS that could be used in a clinical trial setting.  The study will also  provide an opportunity to assess for the first time the impact of Cladribine on cognitive performance using conventional screening tools, detailed neuropsychological batteries, and experimental neurophysiology based paradigms that could be harnessed for future nested case control studies.

Disease area
Motor Neurone Disease
Field of research
Clinical Research
Principal Investigator/ Researcher Names
Prof. Orla Hardiman
Institution
Trinity College Dublin
Start date
Project completed
No
End/expected end date
Funding body

(i) Merck Serono Limited - €190,000

(ii) FutureNeuro SFI Research Centre - €190,000

Grant Awarded (€)
380,000
Are you looking to Recruit Research Participants?
Yes
Research participants information

Recruiting:

(i) Multiple sclerosis patients attending clinics in Beaumont or St. Vincent’s Hospitals.

(ii) Control participants, i.e. participants matched for age and sex without multiple sclerosis.