Dr Darragh O'Brien
Job title
Group Leader in Neurodegenerative Disease
Organisation
University of Oxford
Country
United Kingdom
Broad research area
Basic Science Research
Research interests
Darragh O’Brien is a Group Leader in Translational Proteomics and Neurodegenerative Disease at the Nuffield Department of Medicine, University of Oxford, where he utilises biological mass spectrometry to decipher mechanisms of human disease. His research interests lie in how protein intrinsic disorder and post-translational modifications such as phosphorylation and ubiquitination contribute to protein function and disease, with a focus on the tauopathies Alzheimer's Disease and Progressive Supranuclear Palsy.
Dr O’Brien’s scientific journey began with an Honours Degree in Biochemistry from University College Dublin in 2004, where his undergraduate thesis explored mechanisms of amyloid beta (Aβ) processing in AD, under the guidance of Professor Dominic Walsh. Dr O'Brien subsequently undertook PhD studies in Neuroscience in the group of Professor Sir Simon Lovestone at the Institute of Psychiatry, Psychology & Neuroscience (IoPPN), King’s College London. This was followed by research positions at University College London and Institut Pasteur in Paris. Darragh is a Research Fellow of Green Templeton College, University of Oxford.
Key Words: Alzheimer's Disease, Progressive Supranuclear Palsy, Tauopathies, Dementia, Neuroproteomics, Biomarkers, Neurodegeneration Mechanisms, Drug Discovery, Mass Spectrometry, Structural Biology
Dr O’Brien’s scientific journey began with an Honours Degree in Biochemistry from University College Dublin in 2004, where his undergraduate thesis explored mechanisms of amyloid beta (Aβ) processing in AD, under the guidance of Professor Dominic Walsh. Dr O'Brien subsequently undertook PhD studies in Neuroscience in the group of Professor Sir Simon Lovestone at the Institute of Psychiatry, Psychology & Neuroscience (IoPPN), King’s College London. This was followed by research positions at University College London and Institut Pasteur in Paris. Darragh is a Research Fellow of Green Templeton College, University of Oxford.
Key Words: Alzheimer's Disease, Progressive Supranuclear Palsy, Tauopathies, Dementia, Neuroproteomics, Biomarkers, Neurodegeneration Mechanisms, Drug Discovery, Mass Spectrometry, Structural Biology