Targeting Glial Plasticity to Alleviate Age-related Loss of Neuronal Function in AD.
Project Aim(s): To determine the role of neuroinflammation in driving neurodegeneration.
NeuroSKILL - Neuroimaging Skills in Dementia.
Project Aim(s):
The project has various complementary aims: (a) research on normal ageing and Alzheimer's disease using MRI-based methods, (b) develop training programmes in neuroimaging in dementia, (c) develop greater understanding of the use of neuroimaging by clinicians for diagnosis of Alzheimer's disease, (d) technology transfer between centres.
Investigating Ageing-related Deficits in Cognition: A Combined Multimodal fMRI-DTI.
Project Aim(s): The objective is the assessment of the impact of alterations of white matter tract integrity on effective connectivity in the neural network underpinning working memory. Using brain imaging data it will examine the associations between brain structure and function in young and older healthy participants and how normal ageing alters the relationship between structure and function.
Diet Modification to prevent Aspiration in People with Dementia and Dysphagia.
To determine the evidence for diet modification - Specifically, thickening fluids to prevent aspiration in people with dementia and swallowing difficulties.
Applied Research Projects in Dementia: Validation of the Profile for Communication Abilities in Dementia (P-CAD).
Project Aim(s): To validate a cognitive communication assessment for people with dementia.
Optimising thERapy to prevent Avoidable hospital admissions in the Multimorbid elderly (OPERAM); H2020 PHC-17.
Project Aim(s): To test a software engine designed to optimize medication in multimorbid older patients aimed at preventing unplanned hospitral readmissions.
SENATOR: Development and Clinical Trials of a new Software ENgine for the Assessment & Optimization of Drug and Non-drug Therapy in Older peRsons.
Project Aim(s): To test a software engine for the prevention of adverse drug reactions in multimorbid older patients hospitalized with acute illness.
The Impact of Neuroinflammatory Changes in Deteriorating Cognitive Function in Age and a Model of Alzheimer’s Disease.
To assess whether targeting microglia, and consequently neuroinflammation, can restore impaired cognitive function in age and a model of Alzheimer’s disease.
HeLoCog: Age-related Hearing Loss, Cognitive Function, and the Moderating Roles of Social Isolation and Loneliness.
Aim(s):
(i) To characterise patterns of hearing problems and of hearing aid use in NICOLA and to compare these patterns in a qualitative fashion with those found in TILDA.
(ii) To evaluate the cross-sectional relationship between hearing problems and cognitive functioning, using regression modelling.
(iii) To evaluate loneliness, social isolation, and social engagement as moderators of the putative relationship between hearing problems and cognitive functioning, using a structural equation modelling approach.
Alcohol Consumption & Brain Health in Older Adults Across the Island of Ireland.
Aims are to:
1. Characterise and compare alcohol consumption patterns in older adults in Ireland
2. Determine associations between alcohol patterns and cognitive function