The Trinity-Ulster-Department-of-Agriculture (TUDA) cohort is a unique and innovative resource for ageing research designed to assess the impact of nutritional, lifestyle, environmental and genetic factors on diseases of ageing, particularly in the prevention of cardiovascular disease, dementia and osteoporosis.
The Trinity-Ulster-Department-of-Agriculture (TUDA) cohort is a unique and innovative resource for ageing research designed to assess the impact of nutritional, lifestyle, environmental and genetic factors on diseases of ageing, particularly in the prevention of cardiovascular disease, dementia and osteoporosis.
Project Aim(s): To determine the effect(s) of CSF from Alzheimer's disease (AD) patients on cerebroids cultured healthy human iPSCs and to identify the mediator(s) of AD-CSF-mediated pathology.
Project Aim(s): To utilise brain organoids to investigate the aetiology of Alzheimer's disease.
Project Aim(s): To determine if the ApoE stimulator, bexarotene, can restore dysregulated calcium homeostasis in hippocampal neurons from transgenic AD mice.
Project Aim(s): To determine the role of neuroinflammation in driving neurodegeneration.
Project Aim(s): The objective is the assessment of the impact of alterations of white matter tract integrity on effective connectivity in the neural network underpinning working memory. Using brain imaging data it will examine the associations between brain structure and function in young and older healthy participants and how normal ageing alters the relationship between structure and function.