Dementia/Neurodegeneration Research Database - Research Projects
To develop a self-report questionnaire that measures the fears and coping strategies that develop in response to memory loss
PMSMatTrain focuses on gaining a comprehensive understanding of the progressive phase of multiple sclerosis (PMS) from basics to translation, fully supported by eight beneficiaries (six research institutions and two SMEs).The consortium will develop a multi-modal “tuneable” hydrogel-based medical device designed to bring about biphasic release of anti-inflammatory molecules and neuroprotective drugs as well as generating a clinically-relevant in silico model of drug elution and dispersal within the central nervous system. Using “state-of-the-art” 3D organotypic cultures and disease-relevant oligodendrocytes produced from MS patient-derived stem cells, the project will allow investigation MS pathophysiology as well as analysing the role of therapeutic molecules in combatting inflammation and promoting regeneration and neuroprotection. The industry partners will develop the end-device by providing standardised manufacturing protocols for scaled-up production and commercialisation of the final product.PMSMatTrain is a multidisciplinary European Training Network that will educate and train 15 Early Stage Researchers in functionalised biomaterials, materials science, stem cell biology, in vitro & pre-clinical models, molecular biology, in silico modelling, functionalisation strategies and prototype design.Programme fellows will experience both public and private sector research and development and will be best placed to secure employment as high calibre, innovative and well-trained graduates.
Five students will be based in the CÚRAM lab at NUIG, while the remaining 10 will be based in institutions in Denmark, Germany, France, Spain, Italy, Belgium and the Czech Republic. PIs involved are Prof Trevor Owens (Denmark), Dr Tanja Kuhlmann (Germany), Dr Bertrand Huard (France), Dr Damiana Pierogostina (Italy), Dr. Marlene Verhoye (Belgium), Dr Peter Ponsaerts (Belgium), Dr Martin Pravda (Czech Republic), Dr Anna Rodriguez (Spain).
1. What is the Person with Parkinson's community knowledge and experience of existing voice assisted technology?
2. What is the knowledge, experience and attitudes of Speech and Language Therapists towards voice assisted technology in practice?
Project Aim(s): To determine the effect(s) of CSF from Alzheimer's disease (AD) patients on cerebroids cultured healthy human iPSCs and to identify the mediator(s) of AD-CSF-mediated pathology.
We are a PhD training programme, linking together approximately 90 genomics data science group leaders based at five Irish institutions. Expertise within the group spans from statistical modeling and machine learning to the full range of application of genomics. Over the coming four years our research teams will be joined by 100 fully funded PhD students, recruited through this Centre.
Vision: We are training a generation of highly skilled PhD graduates to harness the collective potential of genomics and data science. Through this unique and intensive PhD programme we want to graduate individuals who will have rich and varied career opportunities and, through them, to have transformative economic and societal impacts in Ireland and further afield.
Training Programme: During the first three months all students will be accommodated on the NUI Galway campus. They will undertake an intensive series of short workshops, presented by leading experts in their fields. At the end of this residential training programme students choose projects and relocate to the partner university at which their research project will commence.
To investigate the psychosocial effects of the introduction of an adaptive Irish Céilí dance group activity with people living with dementia and their carers.
The proposed research aims to create empirical evidence regarding the impact of befriending services on health and loneliness, assisting ALONE in developing and refining their mission statement. The research question is: “Do befriending services improve health (measured as health-related quality of life and cognitive function), and do they mitigate the impact of loneliness on health?” A secondary aim is to identify, using exploratory methods, potential mechanisms through which befriending impacts health.
Aim(s): To examine the impact of VR on the understanding of emotions, cognitions and behaviours for people living with dementia among health professionals and carers.
Aim(s):
(i) To characterise patterns of hearing problems and of hearing aid use in NICOLA and to compare these patterns in a qualitative fashion with those found in TILDA.
(ii) To evaluate the cross-sectional relationship between hearing problems and cognitive functioning, using regression modelling.
(iii) To evaluate loneliness, social isolation, and social engagement as moderators of the putative relationship between hearing problems and cognitive functioning, using a structural equation modelling approach.
(iv) To understand, using semi-structured interviews, the impact of hearing decline in later life on social and cognitive functioning.
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