Dementia/Neurodegeneration Research Database - Research Projects

To develop a self-report questionnaire that measures the fears and coping strategies that develop in response to memory loss

Principal Investigator/ Researchers:
Dr. Francesca Farina
Disease Area:
Dementia (including Alzheimer's Disease and other dementias)
Field of Research:
Social Research
Institution:
Trinity College Dublin
Start year:
2019
Project Completed:
No
Funding body:
Irish Research Council
Recruiting Research Participants?:
Yes

PMSMatTrain focuses on gaining a comprehensive understanding of the progressive  phase of multiple sclerosis (PMS) from basics to translation, fully supported by eight beneficiaries (six research institutions and two SMEs).The consortium will develop a multi-modal “tuneable” hydrogel-based medical device designed to bring about biphasic release of anti-inflammatory molecules and neuroprotective drugs as well as generating a clinically-relevant in silico model of drug elution and dispersal within the central nervous system. Using “state-of-the-art” 3D organotypic cultures and disease-relevant oligodendrocytes produced from MS patient-derived stem cells, the project will allow investigation MS pathophysiology as well as analysing the role of therapeutic molecules in combatting inflammation and promoting regeneration and neuroprotection.  The industry partners will develop the end-device by providing standardised manufacturing protocols for scaled-up production and commercialisation of the final product.PMSMatTrain is a multidisciplinary European Training Network that will educate and train 15 Early Stage Researchers in functionalised biomaterials, materials science, stem cell biology, in vitro & pre-clinical models, molecular biology,  in silico modelling, functionalisation strategies  and prototype design.Programme fellows will experience both public and private sector research and development and will be best placed to secure employment as high calibre, innovative and well-trained graduates.

Five students will be based in the CÚRAM lab at NUIG, while the remaining 10 will be based in institutions in Denmark, Germany, France, Spain, Italy, Belgium and the Czech Republic. PIs involved are Prof Trevor Owens (Denmark), Dr Tanja Kuhlmann (Germany), Dr Bertrand Huard (France), Dr Damiana Pierogostina (Italy), Dr. Marlene Verhoye (Belgium), Dr Peter Ponsaerts (Belgium), Dr Martin Pravda (Czech Republic), Dr Anna Rodriguez (Spain).

Principal Investigator/ Researchers:
Dr. Una FitzGerald
Prof. Abhay Pandit
Dr. Nathan Quinlan
Disease Area:
Neurodegenerative Disease
Field of Research:
Basic/Discovery Research
Institution:
NUI Galway
Start year:
2019
Project Completed:
No
Funding body:
European Union, Innovative Training Network Scheme.  Dr FitzGerald is the lead PI and Coordinator of this doctoral training network. A total of 15 early-stage researchers (PhDs) will be trained in MS- and biomaterial-related research, including brain development, neuroinflammation, neurodegeneration, de- and remyelination.
Recruiting Research Participants?:
No

1. What is the Person with Parkinson's community knowledge and experience of existing voice assisted technology?

2. What is the knowledge, experience and attitudes of Speech and Language Therapists towards voice assisted technology in practice?

Principal Investigator/ Researchers:
Dr Orla Duffy
Professor George Kernohan
Dr Roisin McNaney
Dr Jonathan Synnott
Disease Area:
Parkinson's Disease and related disorders
Field of Research:
Clinical Research
Institution:
Bristol University
University of Ulster
Start year:
2019
Project Completed:
No
Funding body:
N/A
Recruiting Research Participants?:
No
Principal Investigator/ Researchers:
Dr. Lorna Roe
Disease Area:
Neurodegenerative Disease
Field of Research:
Clinical Research
Institution:
Trinity College Dublin
TILDA (The Irish Longitudinal Study on Ageing)
Start year:
2019
Project Completed:
No
Funding body:
Health Research Board (HRB).
Recruiting Research Participants?:
No

Project Aim(s): To determine the effect(s) of CSF from Alzheimer's disease (AD) patients on cerebroids cultured healthy human iPSCs and to identify the mediator(s) of AD-CSF-mediated pathology.

Principal Investigator/ Researchers:
Dr. Mark Rae
Dr. Suzanne Timmons
Disease Area:
Dementia (including Alzheimer's Disease and other dementias)
Field of Research:
Basic/Discovery Research
Institution:
University College Cork (UCC)
Start year:
2019
Project Completed:
Yes
Funding body:
(i) UCC College of Medicine(ii) Health Interdisciplinary Seed Awards
Recruiting Research Participants?:
No

We are a PhD training programme, linking together approximately 90 genomics data science group leaders based at five Irish institutions. Expertise within the group spans from statistical modeling and machine learning to the full range of application of genomics. Over the coming four years our research teams will be joined by 100 fully funded PhD students, recruited through this Centre.

Vision: We are training a generation of highly skilled PhD graduates to harness the collective potential of genomics and data science. Through this unique and intensive PhD programme we want to graduate individuals who will have rich and varied career opportunities and, through them, to have transformative economic and societal impacts in Ireland and further afield.

Training Programme: During the first three months all students will be accommodated on the NUI Galway campus. They will undertake an intensive series of short workshops, presented by leading experts in their fields. At the end of this residential training programme students choose projects and relocate to the partner university at which their research project will commence.

Principal Investigator/ Researchers:
Prof. Cathal Seoighe (Centre Director)
Disease Area:
Neurodegenerative Disease
Field of Research:
Basic/Discovery Research
Institution:
NUI Galway
Start year:
2019
Project Completed:
No
Funding body:
Science Foundation Ireland (SFI).
Recruiting Research Participants?:
No

To investigate the psychosocial effects of the introduction of an adaptive Irish Céilí dance group activity with people living with dementia and their carers.

Principal Investigator/ Researchers:
Seán Dónal O'Shea
Jennifer Moran Stritch
Carmel McKenna
Disease Area:
Dementia (including Alzheimer's Disease and other dementias)
Field of Research:
Social Research
Institution:
Technological University of the Shannon: Midlands/Midwest
Start year:
2018
Project Completed:
Yes
Funding body:
Technological University of the Shannon: Midlands/Midwest; Munster Academy of Dance (in-kind)
Recruiting Research Participants?:
No

The proposed research aims to create empirical evidence regarding the impact of befriending services on health and loneliness, assisting ALONE in developing and refining their mission statement. The research question is: “Do befriending services improve health (measured as health-related quality of life and cognitive function), and do they mitigate the impact of loneliness on health?” A secondary aim is to identify, using exploratory methods, potential mechanisms through which befriending impacts health.

Principal Investigator/ Researchers:
PI: Dr Joanna McHugh Power
Dr. Caoimhe Hannigan
Dr. Paul Hanly
Prof. Brian Lawlor
Prof. Frank Kee
Prof. Tom Scharf
Dr. Robert Coen
Prof. Cathal Walsh
Disease Area:
Dementia (including Alzheimer's Disease and other dementias)
Field of Research:
Public Health
Institution:
Global Brain Health Institute
Trinity College Dublin
Start year:
2018
Project Completed:
No
Funding body:
Health Research Board
Recruiting Research Participants?:
Yes

Aim(s): To examine the impact of VR on the understanding of emotions, cognitions and behaviours for people living with dementia among health professionals and carers.

Principal Investigator/ Researchers:
Dr. Paul Slater
Dr. Felicity Hasson
Dr. Kevin Moor
Florence Sharkey
Disease Area:
Dementia (including Alzheimer's Disease and other dementias)
Field of Research:
Public Health
Institution:
Institute of Nursing and Health Research; Western Health and Social Care Trust
Start year:
2018
Project Completed:
Yes
Funding body:
N/A
Recruiting Research Participants?:
No

Aim(s):

(i) To characterise patterns of hearing problems and of hearing aid use in NICOLA and to compare these patterns in a qualitative fashion with those found in TILDA. 

(ii) To evaluate the cross-sectional relationship between hearing problems and cognitive functioning, using regression modelling. 

(iii) To evaluate loneliness, social isolation, and social engagement as moderators of the putative relationship between hearing problems and cognitive functioning, using a structural equation modelling approach. 

(iv) To understand, using semi-structured interviews, the impact of hearing decline in later life on social and cognitive functioning. 

Principal Investigator/ Researchers:
Dr. Joanna McHugh Power
Prof. Brian Lawlor
Prof. Frank Kee
Dr. David Loughrey
Prof. Jayne Woodside
Disease Area:
Dementia (including Alzheimer's Disease and other dementias)
Field of Research:
Public Health
Institution:
Queen's University Belfast
Trinity College Dublin
Start year:
2018
Project Completed:
No
Funding body:
Centre for Ageing Research and Development in Ireland
Recruiting Research Participants?:
No